Hair care compositions comprising a 2-pyridinol-n-oxide material and an iron chelator

ABSTRACT

The present invention is directed to a hair care composition having an effective amount of a 2-pyridinol-N-oxide material and an effective amount of an iron chelator; wherein the combination of the iron chelator and the 2-pyridinol-N-oxide material provides high anti-fungal efficacy.

FIELD OF THE INVENTION

The present invention is directed to hair care compositions comprising a2-pyridinol-N-oxide material and an effective amount of an ironchelator.

BACKGROUND OF THE INVENTION

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolaminesalt, a 2-pyridinol-N-oxide material, is an anti-dandruff active used inshampoos, conditioners, and other treatments. Surprisingly, iron saltimpurities can reduce the efficacy of 2-pyridinol-N-oxide materials.Therefore, there is a need to develop products that mitigate thisphenomenon and provide higher efficacy. In the present invention it hasbeen found that select iron chelators and 2-pyridinol-N-oxide materialsprovide significantly higher levels of anti-fungal activity than2-pyridinol-N-oxide alone. More importantly and surprisingly and sincesome iron chelators show anti-fungal activity per se, said combinationsof 2-pyridinol-N-oxide and certain iron chelators show anti-fungalactivity significantly higher than the sum of anti-fungal activities ofthe components themselves. By utilizing 2-pyridinol-N-oxide materials incombination with select iron chelators, the present invention deliverscompositions and products with superior anti-dandruff performance.

SUMMARY OF THE INVENTION

The present invention is directed to a hair care composition comprisingan effective amount of a 2-pyridinol-N-oxide material, an effectiveamount of an iron chelator; wherein the combination of the iron chelatorand the 2-pyridinol-N-oxide material provides high anti-fungal efficacy.

DETAILED DESCRIPTION OF THE INVENTION

While the specification concludes with claims which particularly pointout and distinctly claim the invention, it is believed the presentinvention will be better understood from the following description.

The present invention can comprise, consist of, or consist essentiallyof the essential elements and limitations of the invention describedherein, as well any of the additional or optional ingredients,components, or limitations described herein.

All percentages, parts and ratios are based upon the total weight of thecompositions of the present invention, unless otherwise specified. Allsuch weights as they pertain to listed ingredients are based on theactive level and, therefore do not include carriers or by-products thatmay be included in commercially available materials.

The components and/or steps, including those which may optionally beadded, of the various embodiments of the present invention, aredescribed in detail below.

All documents cited are, in relevant part, incorporated herein byreference; the citation of any document is not to be construed as anadmission that it is prior art with respect to the present invention.

All ratios are weight ratios unless specifically stated otherwise.

All temperatures are in degrees Celsius, unless specifically statedotherwise.

Except as otherwise noted, all amounts including quantities,percentages, portions, and proportions, are understood to be modified bythe word “about”, and amounts are not intended to indicate significantdigits.

Except as otherwise noted, the articles “a”, “an”, and “the” mean “oneor more”.

Herein, “comprising” means that other steps and other ingredients whichdo not affect the end result can be added. This term encompasses theterms “consisting of” and “consisting essentially of”. The compositionsand methods/processes of the present invention can comprise, consist of,and consist essentially of the essential elements and limitations of theinvention described herein, as well as any of the additional or optionalingredients, components, steps, or limitations described herein.

Herein, “effective” means an amount of a subject active high enough toprovide a significant positive modification of the condition to betreated. An effective amount of the subject active will vary with theparticular condition being treated, the severity of the condition, theduration of the treatment, the nature of concurrent treatment, and likefactors.

Herein, “hair care compositions” means products for and/or methodsrelating to treating hair (human, dog, and/or cat), including,bleaching, coloring, dyeing, conditioning, growing, removing, retardinggrowth, shampooing, styling; and products and/or methods relating toorally administered materials for enhancing the appearance of hair(human, dog, and/or cat.

The term “2-pyridinol-N-oxide material” encompasses materials thatinclude the unsubstituted 2-pyridinol-N-oxide, substituted2-pyridinol-N-oxide and their salts and tautomeric structures.

Iron Chelators

In the present invention, iron chelators may have, but not be limitedto, the following characteristics:

1. An affinity for iron ions in either the ferrous (iron II) or ferric(III) forms;2. Materials of Description 1 (above) that have a denticity of four orhigher (denticity is the number of groups of a molecule that bind to theiron);3. Chemical descriptions that are a subset of Description 2:

-   -   a. Either natural or synthetic materials;    -   b. Materials of the following chemical classes:        -   i. Aminophosphates        -   ii Aminocarboxylates        -   iii. Hydroxamic acids    -   and molecules representing combinations of these chemical        classes.        In of the present invention, an iron chelator may be present        from the following groups:    -   (1) Iron chelators represented by the following structure:

-   -   where R¹¹, R¹², R¹³, R¹⁴, R¹⁵ are independently selected from        the group consisting of M¹M²PO₃, CO₂M¹, and mixtures thereof    -   where M¹ and M² is H, a metal salt or ammonium salt, wherein        non-limiting examples of the metal salts include Na, K, Ca, Mg,        Al salts.    -   (2) Iron chelators represented by the following structure:

-   -   -   where a is an integer from 2 to 7 wherein any of the CH₂            groups in this unit may be substituted with alkyl or aryl            units that may contain heteroatoms (S, N, O, Cl, F, Br or I)        -   where b is an integer from 1 to 7 wherein any of the CH₂            groups in this unit may be substituted with alkyl or aryl            units that may contain heteroatoms (S, N, O, Cl, F, Br or I)        -   where R¹⁶ is H or (CH₂)_(n), where n in an integer from 1 to            6 or is a CH₂ linker unit that may be further substituted at            any CH₂ group in the chain with alkyl or aryl units that may            contain heteroatoms (S, N, O, Cl, F, Br, or I).

Non-limiting examples of iron chelators includediethylenetriaminepentaacetic acid (DTPA), Diethylenetriaminepentakis(methylenephosphonic acid) (DTPMP), Desferrioxamine, their salts andcombinations thereof. The present invention may contain from about 0.01%to about 15% of an iron chelator, alternatively from about 0.3% to about6%, and alternatively from about 0.5% to about 4%.

2-Pyridinol-N-Oxide Materials

2-Pyridinol-N-oxide materials suitable for use in this invention includea substituted or unsubstituted 2-pyridinol-N-oxide material or a saltthereof. Included within the scope of this invention are tautomers ofthis material, e.g., 1-hydroxy-2(1H)-pyridinone. The substituted orunsubstituted 2-pyridinol-N-oxide material and its correspondingtautomeric form, 1-hydroxy-2(1H)-pyridinone, are shown below:

where R¹, R², R³, R⁴ groups are independently selected from the groupconsisting of H, Cl, Br, I, F, NO, NO₂, and (CH₂)_(n)G, where each G isindependently selected from the group consisting of (O)_(m)SO₃M³,(O)_(m)CO₂M³, (O)_(m)C(O)(R⁵), (O)_(m)C(O)N(R⁵R⁶), (O)_(m)CN,(O)_(m)(R⁵), and N(R⁵R⁶), where m is 0 or 1, n is an integer from 0 to4, R⁵ and R⁶ are independently selected from the group consisting of Hand a substituted or unsubstituted C₁-C₁₂ organic group, and M³ isselected from the group consisting of H, a substituted or unsubstitutedC₁-C₁₂ organic group, +N(R⁷R⁸R⁹R¹⁰), and 1/q M′^(q+) where M′ isselected from the group consisting of an alkali metal of charge q and analkaline earth metal of charge q, where R7, R8, R9, and R10 areindependently selected from the group consisting of H and a substitutedor unsubstituted C₁-C₁₂ organic group, and where any pair of vicinalgroups, R¹ and R², R² and R³, R³ and R⁴ may be taken together to formanother five- or six-membered aromatic or aliphatic ring optionallysubstituted with one or more groups selected from the group consistingof Cl, Br, I, F, NO, NO₂, CN, (CH₂)_(n)G, and mixtures thereof. Suitableorganic groups include (C₁-C₁₂)alkyl, (C₂-C₁₂)alkenyl, and(C₂-C₁₂)alkynyl. The organic group may optionally be substituted andsuitable substituent groups include a hydroxyl group, a carboxyl group,and an amino group. 2-pyridinol-N-oxide is also known, for example, as2-hydroxypyridine-N-oxide, 2-pyridinol-1-oxide, or2-hydroxypyridine-1-oxide.

In certain aspects, the 2-pyridinol-N-oxide material is a2-pyridinol-N-oxide material or tautomer thereof according to theformula(s) above, where R¹, R², R³, R⁴ are independently selected fromthe group consisting of H, Cl, and (CH₂)_(n)G, where G is independentlyselected from the group consisting of (O)_(m)SO₃M³, (O)_(m)CO₂M³,(O)_(m)C(O)(R⁵), (O)_(m)CN, and (O)_(m)(R⁵), where m is 0 or 1. In otheraspects, the 2-pyridinol-N-oxide material is a 2-pyridinol-N-oxidematerial according to the formula above, where R¹, R², R³, R⁴ areindependently selected from the group consisting of H, SO₃M³, and CO₂M³.In still other aspects, R¹, R², R³, R⁴ are independently selected fromthe group consisting of H, SO₃M³, and CO₂M³, where no more than one R¹,R², R³, R⁴ is SO₃M³ or CO₂M³.

In certain aspects, the 2-pyridinol-N-oxide material is the salt of asubstituted or unsubstituted 2-pyridinol-N-oxide material. In theseaspects, the hydrogen of the hydroxyl group of the 2-pyridinol-N-oxidematerial may be substituted with a suitable charge-balancing cation. Inthese aspects, non-limiting examples of the hydrogen-substituting cationinclude Na⁺, Li⁺, K⁺, ½Mg²⁺, or ½ Ca²⁺, substituted ammonium, such asC₁-C₆ alkanolammnonium, mono-ethanolamine (MEA), tri-ethanolamine (TEA),di-ethanolamine (DEA), or any mixture thereof. In some aspects, insolution, the cation may be dissociated from the 2-pyridinol-N-oxide orthe 1-hydroxy-2(1H)-pyridinone anion.

In certain aspects, the 2-pyridinol-N-oxide material is of a substitutedor unsubstituted 2-pyridinol-N-oxide material. Salts for use hereininclude those formed from the polyvalent metals barium, bismuth,strontium, copper, zinc, cadmium, zirconium and mixtures thereof.

In some aspects, the 2-pyridinol-N-oxide material is selected from thegroup consisting of: 6-hydroxy-3-pyridinesulfonic acid, 1-oxide (CAS191672-18-1); 2-hydroxypyridine-1-oxide (CAS 13161-30-3);2-hydroxy-4-pyridinecarboxylic acid, 1-oxide (CAS 13602-64-7);5-ethoxy-2-pyridinol, 2-acetate, 1-oxide (CAS 51984-49-7);1-(3-hydroxy-2-oxido-4-isoquinolinyl)-ethanone (CAS 65417-65-4);6-hydroxy-3-pyridinecarboxylic acid, 1-oxide (CAS 90037-89-1);2-methoxy-4-quinolinecarbonitrile, 1-oxide (CAS 379722-76-6);2-pyridinecarboxylic acid, 6-hydroxy-, 1-oxide (CAS 1094194-45-2);3-pyridinecarboxylic acid, 2-hydroxy-, 1-oxide (CAS 408538-43-2);2-pyridinol, 3-nitro-, 1-oxide (CAS 282102-08-3);3-pyridinepropanenitrile, 2-hydroxy-, 1-oxide (193605-60-6);3-pyridineethanol, 2-hydroxy-, 3-acetate, 1-oxide (CAS 193605-56-0);2-pyridinol, 4-bromo-, 1-oxide (CAS 170875-41-9); 2-pyridinol,4,6-dibromo-, 2-acetate, 1-oxide (CAS 170875-40-8); 2-pyridinol,4,6-dibromo, 1-oxide (CAS 170875-38-4); 2-pyridinol, 4-(2-aminoethyl)-,1-oxide (CAS 154403-93-7); 2-pyridinol, 5-(2-aminoethyl)-, 1-oxide (CAS154403-92-6); 3-pyridinepropanoic acid, α-amino-6-hydroxy-, 1-oxide (CAS134419-61-7); 2-pyridinol, 3,5-dimethyl, 1-oxide (CAS 102074-62-4);2-pyridinol, 3-methyl-, 1-oxide (CAS 99969-07-0); 2-pyridinol,3,5-dinitro, 1-oxide (CAS 98136-47-1); 2-pyridinol, 3,5-dibromo-,1-oxide (CAS 98136-29-9); 2-pyridinol, 4-methyl-6-(2-methylpropyl)-,1-oxide (CAS 91408-77-4); 2-pyridinol, 3-bromo-4,6-dimethyl-, 1-oxide(CAS 91408-76-3); 2-pyridinol, 4,5,6-trimethyl-, 1-oxide (CAS91408-75-2); 2-pyridinol, 6-heptyl-4-methyl-, 1-oxide (CAS 91408-73-0);2-pyridinol, 6-(cyclohexylmethyl)-4-methyl-, 1-oxide (CAS 91408-72-9);2-pyridinol, 6-bromo-, 1-oxide (CAS 89284-00-4); 2-pyridinol, 5-bromo-,1-oxide (CAS 89283-99-8); 2-pyridinol, 3,5-dichloro-4,6-difluoro-,1-oxide (CAS 33693-37-7); 2-pyridinol, 3,4,5,6-tetrachloro-, 1-oxide(CAS 32835-63-5); 2-pyridinol, 6-methyl-, 1-oxide (CAS 14420-62-3);2-pyridinol, 5-nitro-, 1-oxide (CAS 14396-03-3); 2-pyridinol,4-methyl-5-nitro-, 1-oxide (CAS 13602-77-2); 2-pyridinol,4-chloro-5-nitro-, 1-oxide (CAS 13602-73-8); 2-pyridinol, 4-chloro-,1-oxide (CAS 13602-65-8); 2-pyridinol, 4-nitro-, 1-oxide (CAS13602-63-6); and 2-pyridinol, 4-methyl-, 1-oxide (CAS 1952-64-3), andmixtures thereof. These materials are commercially available from, forexample, Sigma-Aldrich (St. Louis, Mo.) and/or Aces Pharma (Branford,Conn.).

In certain aspects, the 2-pyridinol-N-oxide material is a2-pyridinol-N-oxide material selected from the group consisting of:2-hydroxypyridine-1-oxide; 3-pyridinecarboxylic acid, 2-hydroxy-,1-oxide; 6-hydroxy-3-pyridinecarboxylic acid, 1-oxide;2-hydroxy-4-pyridinecarboxylic acid, 1-oxide; 2-pyridinecarboxylic acid,6-hydroxy-, 1-oxide; 6-hydroxy-3-pyridinesulfonic acid, 1-oxide; andmixtures thereof.

In certain aspects, the 2-pyridinol-N-oxide material is a1-Hydroxy-2(1H)-pyridinone material selected from the group consistingof: 1-Hydroxy-2(1H)-pyridinone (CAS 822-89-9);1,6-dihydro-1-hydroxy-6-oxo-3-Pyridinecarboxylic acid (CAS 677763-18-7);1,2-dihydro-1-hydroxy-2-oxo-4-Pyridinecarboxylic acid (CAS 119736-22-0);1,6-dihydro-1-hydroxy-6-oxo-2-Pyridinecarboxylic acid (CAS 94781-89-2);1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-Pyridinone (CAS50650-76-5); 6-(cyclohexylmethyl)-1-hydroxy-4-methyl-2(1H)-Pyridinone(CAS 29342-10-7); 1-hydroxy-4,6-dimethyl-2(1H)-Pyridinone (CAS29342-02-7); 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridonemonoethanolamine (CAS 68890-66-4);1-hydroxy-6-(octyloxy)-2(1H)-Pyridinone (CAS 162912-64-3);1-Hydroxy-4-methyl-6-cyclohexyl-2-pyridinone ethanolamine salt (CAS41621-49-2); 1-Hydroxy-4-methyl-6-cyclohexyl-2-pyridinone (CAS29342-05-0); 6-ethoxy-1,2-dihydro-1-hydroxy-2-oxo-4-Pyridinecarboxylicacid, methyl ester (CAS 36979-78-9); 1-hydroxy-5-nitro-2(1H)-Pyridinone(CAS 45939-70-6); and mixtures thereof. These materials are commerciallyavailable from, for example, Sigma-Aldrich (St. Louis, Mo.), PrincetonBuilding Blocks (Monmouth Junction, N.J.), 3B Scientific Corporation(Libertyville, Ill.), SynFine Research (Richmond Hill, ON), RyanScientific, Inc. (Mt. Pleasant, S.C.), and/or Aces Pharma (Branford,Conn.).

In certain aspects, the 2-pyridinol-N-oxide material is a2-pyridinol-N-oxide material or tautomer thereof according to theformula(s) below:

where X is an oxygen or sulfur moiety and R is a substituted orunsubstituted hydrocarbon group having between 1 and 20 carbon atoms.Materials of this class can be synthesized following the proceduredisclosed in U.S. Pat. No. 5,675,013.

In certain aspects, the 2-pyridinol-N-oxide material is a2-pyridinol-N-oxide material or tautomer thereof according to theformula(s) below:

Wherein R′ and R″ are independently either hydrogen or a substituted orunsubstituted hydrocarbon group having between 1 and 20 carbon atoms.Materials of this class can be synthesized following the proceduredisclosed in U.S. Pat. No. 5,675,013. In certain aspects, the2-pyridinol-N-oxide material is1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolaminesalt.

In the present invention, the hair care composition may contain fromabout 0.1% to about 10% of a substituted or unsubstituted 2-pyridinolN-oxide material. Alternatively, the hair care composition may containfrom about 0.3% to about 3% of a substituted or unsubstituted2-pyridinol N-oxide material. Alternatively, the hair care compositionmay contain from about 0.5% to about 2% of a substituted orunsubstituted 2-pyridinol N-oxide material.

Minimum Inhibitory Concentration (MIC)

The minimum inhibitory concentration (MIC) is the inhibitorconcentration that causes growth inhibition so that the culture opticaldensity less than or equal to ⅕ (20%) of the culture optical density ofthe untreated control.

To measure the growth inhibition properties of test materials againstMalassezia, the following protocol is followed. The Malassezia furfur iscultured in 50 ml M. Dixon medium (per one liter: 36 g malt extract(Difco 0186-17), 20 g ox bile (Fluka 70168), 10 ml Tween 40 (Aldrich27435-6), 6 g peptone (Difco 0118-17), 2 ml oleic acid (Baker 2114-01),and 2 ml glycerol (Sigma G-7893. The pH is adjusted to 5.5 using 1N HCl.The media is autoclaved.

Starting cultures are prepared by incubating freezer stocks with shakingat 33° C. The inoculum of Malassezia cells is 5.5×10⁵ cfu/ml. Cells areincubated at 33° C. for two days. After the two day incubation opticaldensity is read and background subtracted. MIC values are determined byaveraging the results from two replicate experiments.

TABLE 1 Minimum inhibitory concentrations (MIC) of materials MICMaterial (ppm) 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone25 monoethanolamine salt Desferrioxamine >400Diethylenetriaminepentaacetic acid (DTPA) >400Diethylenetriaminepentakis(methylenephosphonic acid) >400 (DTPMP)

Modified Fractional Inhibitory Concentration (MFIC)

A Modified Fractional Inhibitory Concentration (MFIC) is used todetermine the combinatorial effects of two chemicals on anti-Malasseziaactivity in a tissue culture setting. MFIC is a measure of theanti-Malassezia activity of concentrations of a substituted orunsubstituted 2-pyridinol-N-oxide material that are less than thesubstituted or unsubstituted 2-pyridinol-N-oxide material's MIC, incombination with other materials.

I. Method Overview:

-   -   1. Each MFIC assay is run in duplicate.    -   2. Low levels of M.Furfur 7892 cells are inoculated into each        well of a 96 well plate.    -   3. Chemical #1 (in our assays this is always a        2-pyridinol-N-oxide material) is added at a concentration equal        to ½ the concentration of its MIC concentration.    -   4. Chemical #2 is titrated (2× concentration reduction) across        each well in the same row, starting at 400 ppm.    -   5. Plates are incubated at 33° C. for 2 days.    -   6. Optical densities (OD's) are then determined using a        spectrophotometer.

II. Data Analysis

-   -   1. Inhibition of growth is determined if the culture optical        density is less than or equal to ⅕ (20%) of the culture optical        density of the untreated control    -   2. The MFIC is determined as the average value of the lowest        concentration value of Material #2 that inhibits growth.

TABLE 2 Modified Fractional Inhibitory concentrations of combinations ofmaterials. MFIC Material #1 Material #2 (ppm)1-hydroxy-4-methyl-6-(2,4,4- Desferrioxamine 5trimethylpentyl)-2-pyridone monoethanolamine salt1-hydroxy-4-methyl-6-(2,4,4- Diethylenetriaminepentaacetic 37trimethylpentyl)-2-pyridone acid (DTPA) monoethanolamine salt1-hydroxy-4-methyl-6-(2,4,4- Diethylenetri- 50trimethylpentyl)-2-pyridone aminepentakis(methylenephos-monoethanolamine salt phonic acid) (DTPMP) 1-hydroxy-4-methyl-6-(2,4,4-EDTA 150 trimethylpentyl)-2-pyridone monoethanolamine salt

A lower MFIC value indicates a higher level of efficacy for acombination of materials. The MFIC value of1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolaminesalt in combination with EDTA is greater than 100 ppm, indicating thiscombination has a low level of efficacy.

D. Iron Affinity—Log K₁

The strength of the association between a ligand and metal, in this caseiron, can be termed iron affinity. A high iron binding affinity isrequired for chelators to effectively compete with iron salt impuritiesthat reduce the efficacy of 2-pyridinol-N-oxide materials.

Affinity between a metal (M) and ligand (L) can be measured by thestepwise association constant, K₁ which describes the followingequilibrium:

$\left. {M + L}\rightleftharpoons{ML} \right.;{K_{1} = \frac{\lbrack{ML}\rbrack}{\lbrack M\rbrack \lbrack L\rbrack}}$

The affinity constant is conveniently expressed as the logarithm (logK₁) and the larger the magnitude of this number, the stronger theassociation between the metal (iron ions in this case) and ligand.

TABLE 3 Iron Binding Affinities of Chelators and their MFIC Values MFICChelator Log K₁ ^(a) (ppm) Desferrioxamine 31 5Diethylenetriaminepentaacetic acid (DTPA) 28 37Diethylenetriaminepentakis(methylenephosphonic 23 50 acid) (DTPMP)Methylglycine diacetic acid (MGDA) 16 >400 Citric Acid 11 >400 ^(a) NISTStandard Reference Database 46: Critically Selected Stability Constantsof Metal Complexes.

In the present invention, the hair care composition may contain an ironchelator which has a log K₁ greater than about 16. Alternatively, thehair care composition may contain an iron chelator which has a log K₁greater than about 20.

The hair care composition of the present invention may be a shampoo, arinse-off hair conditioner or a leave-on treatment.

Shampoo Composition

The hair care composition of the present invention can be a shampoo. Theshampoo composition delivers consumer desired shampooing in addition toscalp anti-dandruff efficacy benefit.

The shampoo composition may comprise from about 0.1 wt % to about 10.0wt %, alternatively, from about 0.3 wt % to about 3.0 wt %,alternatively from about 0.5% to about 2% of a substituted orunsubstituted 2-pyridinol-N-oxide material in an aqueous carrier. Theshampoo composition may also comprise from about 0.01 wt % to about 15.0wt %, alternatively from about 0.3 wt % to about 6.0 wt %, alternativelyfrom about 0.5% to about 4% of a chelator.

After applying to the hair a shampoo composition as described herein,the shampoo is rinsed from the hair using water.

A. Detersive Surfactant

The shampoo composition may comprise one or more detersive surfactants,which provides cleaning performance to the composition. The one or moredetersive surfactants in turn may comprise an anionic surfactant,amphoteric or zwitterionic surfactants, or mixtures thereof. Variousexamples and descriptions of detersive surfactants are set forth in U.S.Pat. No. 6,649,155; U.S. Patent Application Publication No.2008/0317698; and U.S. Patent Application Publication No. 2008/0206355,which are incorporated herein by reference in their entirety.

The concentration of the detersive surfactant component in the shampoocomposition should be sufficient to provide the desired cleaning andlather performance, and generally ranges from about 2 wt % to about 50wt %, from about 5 wt % to about 30 wt %, from about 8 wt % to about 25wt %, from about 10 wt % to about 20 wt %, about 5 wt %, about 10 wt %,about 12 wt %, about 15 wt %, about 17 wt %, about 18 wt %, or about 20wt %.

Anionic surfactants suitable for use in the compositions are the alkyland alkyl ether sulfates. Other suitable anionic surfactants are thewater-soluble salts of organic, sulfuric acid reaction products. Stillother suitable anionic surfactants are the reaction products of fattyacids esterified with isethionic acid and neutralized with sodiumhydroxide. Other similar anionic surfactants are described in U.S. Pat.Nos. 2,486,921; 2,486,922; and 2,396,278, which are incorporated hereinby reference in their entirety.

Exemplary anionic surfactants for use in the shampoo composition includeammonium lauryl sulfate, ammonium laureth sulfate, triethylamine laurylsulfate, triethylamine laureth sulfate, triethanolamine lauryl sulfate,triethanolamine laureth sulfate, monoethanolamine lauryl sulfate,monoethanolamine laureth sulfate, diethanolamine lauryl sulfate,diethanolamine laureth sulfate, lauric monoglyceride sodium sulfate,sodium lauryl sulfate, sodium laureth sulfate, potassium lauryl sulfate,potassium laureth sulfate, sodium lauryl sarcosinate, sodium lauroylsarcosinate, lauryl sarcosine, cocoyl sarcosine, ammonium cocoylsulfate, ammonium lauroyl sulfate, sodium cocoyl sulfate, sodium lauroylsulfate, potassium cocoyl sulfate, potassium lauryl sulfate,triethanolamine lauryl sulfate, triethanolamine lauryl sulfate,monoethanolamine cocoyl sulfate, monoethanolamine lauryl sulfate, sodiumtridecyl benzene sulfonate, sodium dodecyl benzene sulfonate, sodiumcocoyl isethionate and combinations thereof. Alternatively, the anionicsurfactant is sodium lauryl sulfate or sodium laureth sulfate.

Suitable amphoteric or zwitterionic surfactants for use in the shampoocomposition herein include those which are known for use in shampoo orother personal care cleansing. Concentrations of such amphotericsurfactants range from about 0.5 wt % to about 20 wt %, and from about 1wt % to about 10 wt %. Non limiting examples of suitable zwitterionic oramphoteric surfactants are described in U.S. Pat. Nos. 5,104,646 and5,106,609, which are incorporated herein by reference in their entirety.

Amphoteric detersive surfactants suitable for use in the shampoocomposition include those surfactants broadly described as derivativesof aliphatic secondary and tertiary amines in which the aliphaticradical can be straight or branched chain and wherein one of thealiphatic substituents contains from about 8 to about 18 carbon atomsand one contains an anionic group such as carboxy, sulfonate, sulfate,phosphate, or phosphonate. Exemplary amphoteric detersive surfactantsfor use in the present shampoo composition include cocoamphoacetate,cocoamphodiacetate, lauroamphoacetate, lauroamphodiacetate, and mixturesthereof.

Zwitterionic detersive surfactants suitable for use in the shampoocomposition include those surfactants broadly described as derivativesof aliphatic quaternaryammonium, phosphonium, and sulfonium materials,in which the aliphatic radicals can be straight or branched chain, andwherein one of the aliphatic substituents contains from about 8 to about18 carbon atoms and one contains an anionic group such as carboxy,sulfonate, sulfate, phosphate or phosphonate. Alternatively,zwitterionics such as betaines are selected.

Non limiting examples of other anionic, zwitterionic, amphoteric oroptional additional surfactants suitable for use in the shampoocomposition are described in McCutcheon's, Emulsifiers and Detergents,1989 Annual, published by M. C. Publishing Co., and U.S. Pat. Nos.3,929,678, 2,658,072; 2,438,091; 2,528,378, which are incorporatedherein by reference in their entirety.

The shampoo composition may also comprise a shampoo gel network, anaqueous carrier, and other additional ingredients described herein.

B. Aqueous Carrier

The shampoo composition comprises a first aqueous carrier. Accordingly,the formulations of the shampoo composition can be in the form ofpourable liquids (under ambient conditions). Such compositions willtherefore typically comprise a first aqueous carrier, which is presentat a level of at least 20 wt %, from about 20 wt % to about 95 wt %, orfrom about 60 wt % to about 85 wt %. The first aqueous carrier maycomprise water, or a miscible mixture of water and organic solvent, andin one aspect may comprise water with minimal or no significantconcentrations of organic solvent, except as otherwise incidentallyincorporated into the composition as minor ingredients of othercomponents.

The first aqueous carriers useful in the shampoo composition includewater and water solutions of lower alkyl alcohols and polyhydricalcohols. The lower alkyl alcohols useful herein are monohydric alcoholshaving 1 to 6 carbons, in one aspect, ethanol and isopropanol. Thepolyhydric alcohols useful herein include propylene glycol, hexyleneglycol, glycerin, and propane diol.

C. Shampoo Gel Matrix

The shampoo composition described herein may comprise a shampoo gelnetwork. The shampoo gel network comprises (i) from about 0.1% to about20% of one or more fatty alcohols, alternatively, from about 0.5% toabout 14%, alternatively, from about 1% to about 10%, alternatively,from about 6% to about 8%, by weight of the shampoo gel network; (ii)from about 0.1% to about 10% of one or more shampoo gel networksurfactants, by weight of the shampoo gel network; and (iii) from about20% to about 95% of an aqueous carrier, alternatively, from about 60% toabout 85% by weight of the shampoo gel network.

The fatty alcohols useful herein are those having from about 10 to about40 carbon atoms, from about 12 to about 22 carbon atoms, from about 16to about 22 carbon atoms, or about 16 to about 18 carbon atoms. Thesefatty alcohols can be straight or branched chain alcohols and can besaturated or unsaturated. Nonlimiting examples of fatty alcoholsinclude, cetyl alcohol, stearyl alcohol, behenyl alcohol, and mixturesthereof. Mixtures of cetyl and stearyl alcohol in a ratio of from about20:80 to about 80:20 are suitable.

The shampoo gel network surfactants may be any of the detersivesurfactants described in section “A” herein.

The aqueous carrier may comprise water, or a miscible mixture of waterand organic solvent, and in one aspect may comprise water with minimalor no significant concentrations of organic solvent, except as otherwiseincidentally incorporated into the composition as minor ingredients ofother components.

The aqueous carrier useful herein includes water and water solutions oflower alkyl alcohols and polyhydric alcohols. The lower alkyl alcoholsuseful herein are monohydric alcohols having 1 to 6 carbons, in oneaspect, ethanol and isopropanol. Exemplary polyhydric alcohols usefulherein include propylene glycol, hexylene glycol, glycerin, and propanediol.

Conditioner Composition

Hair conditioners are typically applied on hair after rinsing theshampoo composition from the hair. The conditioner composition describedherein delivers consumer desired hair conditioning in addition toanti-dandruff benefits.

The conditioner composition comprises from about 0.1 wt % to about 10.0wt %, alternatively, from about 0.3 wt % to about 3.0 wt %,alternatively, from about 0.5% to about 2% of a 2-pyridinol-N-oxidematerial in an aqueous carrier. The conditioner composition alsocomprises from about 0.1 wt % to about 15.0 wt %, alternatively, fromabout 0.3 wt % to about 3.0 wt %, alternatively, from about 0.5% toabout 2% of a chelator. The conditioner composition described herein mayalso comprise a conditioner gel matrix comprising (1) one or more highmelting point fatty materials, (2) a cationic surfactant system, and (3)a second aqueous carrier. After applying to the hair a conditionercomposition, the conditioner is rinsed from the hair using water.

A. Cationic Surfactant System

The conditioner gel matrix of the conditioner composition includes acationic surfactant system. The cationic surfactant system can be onecationic surfactant or a mixture of two or more cationic surfactants.The cationic surfactant system can be selected from: mono-long alkylquaternized ammonium salt; a combination of mono-long alkyl quaternizedammonium salt and di-long alkyl quaternized ammonium salt; mono-longalkyl amidoamine salt; a combination of mono-long alkyl amidoamine saltand di-long alkyl quaternized ammonium salt, a combination of mono-longalkyl amindoamine salt and mono-long alkyl quaternized ammonium salt.

The cationic surfactant system can be included in the composition at alevel by weight of from about 0.1% to about 10%, from about 0.5% toabout 8%, from about 0.8% to about 5%, and from about 1.0% to about 4%.

Mono-Long Alkyl Quaternized Ammonium Salt

The monoalkyl quaternized ammonium salt cationic surfactants usefulherein are those having one long alkyl chain which has about 22 carbonatoms and alternatively, a C22 alkyl group. The remaining groupsattached to nitrogen are independently selected from an alkyl group offrom 1 to about 4 carbon atoms; or an aryl group; or an alkoxy,polyoxyalkylene, alkylamido, hydroxyalkyl, or alkylaryl group having upto about 4 carbon atoms.

Mono-long alkyl quaternized ammonium salts useful herein are thosehaving the formula (I):

wherein one of R⁷⁵, R⁷⁶, R⁷⁷ and R⁷⁸ is selected from an alkyl group of22 carbon atoms or an aromatic group; or an aryl group; or an alkoxy,polyoxyalkylene, alkylamido, hydroxyalkyl, or alkylaryl group having upto about 30 carbon atoms; the remainder of R⁷⁵, R⁷⁶, R⁷⁷ and R⁷⁸ areindependently selected from an alkyl group of from 1 to about 4 carbonatoms; or an aryl group; or an alkoxy, polyoxyalkylene, alkylamido,hydroxyalkyl, or alkylaryl group having up to about 4 carbon atoms; andX⁻ is a salt-forming anion such as those selected from halogen, (e.g.chloride, bromide), acetate, citrate, lactate, glycolate, phosphate,nitrate, sulfonate, sulfate, alkylsulfate, and alkyl sulfonate radicals.The alkyl groups can contain, in addition to carbon and hydrogen atoms,ether and/or ester linkages, and other groups such as amino groups. Thelonger chain alkyl groups, e.g., those of about 22 carbons, or higher,can be saturated or unsaturated. One of R⁷⁵, R⁷⁶, R⁷⁷ and R⁷⁸ can beselected from an alkyl group of about 22 carbon atoms, the remainder ofR⁷⁵, R⁷⁶, R⁷⁷ and R⁷⁸ are independently selected from CH₃, C₂H₅, C₂H₄OH,and mixtures thereof; and X is selected from the group consisting of Cl,Br, CH₃OSO₃, C₂H₅OSO₃, and mixtures thereof.

Nonlimiting examples of such mono-long alkyl quaternized ammonium saltcationic surfactants include: behenyl trimethyl ammonium salt.

Mono-Long Alkyl Amidoamine Salt

Mono-long alkyl amines are also suitable as cationic surfactants.Primary, secondary, and tertiary fatty amines are useful. Particularlyuseful are tertiary amido amines having an alkyl group of about 22carbons. Exemplary tertiary amido amines include:behenamidopropyldimethylamine, behenamidopropyldiethylamine,behenamidoethyldiethylamine, behenamidoethyldimethylamin. Useful aminesin the present invention are disclosed in U.S. Pat. No. 4,275,055,Nachtigal, et al. These amines can also be used in combination withacids such as l-glutamic acid, lactic acid, hydrochloric acid, malicacid, succinic acid, acetic acid, fumaric acid, tartaric acid, citricacid, l-glutamic hydrochloride, maleic acid, and mixtures thereof;alternatively, L-glutamic acid, lactic acid, and/or citric acid. Theamines herein can be partially neutralized with any of the acids at amolar ratio of the amine to the acid of from about 1:0.3 to about 1:2,and/or from about 1:0.4 to about 1:1.

Di-Long Alkyl Quaternized Ammonium Salt

Di-long alkyl quaternized ammonium salt can be combined with a mono-longalkyl quaternized ammonium salt or mono-long alkyl amidoamine salt. Itis believed that such combination can provide easy-to rinse feel,compared to single use of a monoalkyl quaternized ammonium salt ormono-long alkyl amidoamine salt. In such combination with a mono-longalkyl quaternized ammonium salt or mono-long alkyl amidoamine salt, thedi-long alkyl quaternized ammonium salts are used at a level such thatthe wt % of the dialkyl quaternized ammonium salt in the cationicsurfactant system is in the range of from about 10% to about 50%, and/orfrom about 30% to about 45%.

The di-long alkyl quaternized ammonium salt cationic surfactants usefulherein are those having two long alkyl chains having about 22 carbonatoms. The remaining groups attached to nitrogen are independentlyselected from an alkyl group of from 1 to about 4 carbon atoms; or anaryl group; or an alkoxy, polyoxyalkylene, alkylamido, hydroxyalkyl, oralkylaryl group having up to about 4 carbon atoms.

Di-long alkyl quaternized ammonium salts useful herein are those havingthe formula (II):

wherein two of R⁷⁵, R⁷⁶, R⁷⁷ and R⁷⁸ is selected from an alkyl group offrom 22 carbon atoms; or an aromatic group; or an aryl group; or analkoxy, polyoxyalkylene, alkylamido, hydroxyalkyl, aryl or alkylarylgroup having up to about 30 carbon atoms; the remainder of R⁷⁵, R⁷⁶, R⁷⁷and R⁷⁸ are independently selected from an alkyl group of from 1 toabout 4 carbon atoms or an alkoxy, polyoxyalkylene, alkylamido,hydroxyalkyl, aryl or alkylaryl group having up to about 4 carbon atoms;and X⁻ is a salt-forming anion such as those selected from halogen,(e.g. chloride, bromide), acetate, citrate, lactate, glycolate,phosphate, nitrate, sulfonate, sulfate, alkylsulfate, and alkylsulfonate radicals. The alkyl groups can contain, in addition to carbonand hydrogen atoms, ether and/or ester linkages, and other groups suchas amino groups. The longer chain alkyl groups, e.g., those of about 22carbons, or higher, can be saturated or unsaturated. One of R⁷⁵, R⁷⁶,R⁷⁷ and R⁷⁸ can be selected from an alkyl group of from 22 carbon atoms,the remainder of R⁷⁵, R⁷⁶, R⁷⁷ and R⁷⁸ are independently selected fromCH₃, C₂H₅, C₂H₄OH, and mixtures thereof; and X is selected from thegroup consisting of Cl, Br, CH₃OSO₃, C₂H₅OSO₃, and mixtures thereof.

Such dialkyl quaternized ammonium salt cationic surfactants include, forexample, dialkyl (C22) dimethyl ammonium chloride, ditallow alkyldimethyl ammonium chloride, dihydrogenated tallow alkyl dimethylammonium chloride. Such dialkyl quaternized ammonium salt cationicsurfactants also include, for example, asymmetric dialkyl quaternizedammonium salt cationic surfactants.

B. High Melting Point Fatty Compound

The conditioner gel matrix of the conditioner composition includes oneor more high melting point fatty compounds. The high melting point fattycompounds useful herein may have a melting point of 25° C. or higher,and is selected from the group consisting of fatty alcohols, fattyacids, fatty alcohol derivatives, fatty acid derivatives, and mixturesthereof. It is understood by the artisan that the compounds disclosed inthis section of the specification can in some instances fall into morethan one classification, e.g., some fatty alcohol derivatives can alsobe classified as fatty acid derivatives. However, a given classificationis not intended to be a limitation on that particular compound, but isdone so for convenience of classification and nomenclature. Further, itis understood by the artisan that, depending on the number and positionof double bonds, and length and position of the branches, certaincompounds having certain carbon atoms may have a melting point of lessthan 25° C. Such compounds of low melting point are not intended to beincluded in this section. Nonlimiting examples of the high melting pointcompounds are found in International Cosmetic Ingredient Dictionary,Fifth Edition, 1993, and CTFA Cosmetic Ingredient Handbook, SecondEdition, 1992.

Among a variety of high melting point fatty compounds, fatty alcoholsare suitable for use in the conditioner composition. The fatty alcoholsuseful herein are those having from about 14 to about 30 carbon atoms,from about 16 to about 22 carbon atoms. These fatty alcohols aresaturated and can be straight or branched chain alcohols. Suitable fattyalcohols include, for example, cetyl alcohol, stearyl alcohol, behenylalcohol, and mixtures thereof.

High melting point fatty compounds of a single compound of high puritycan be used. Single compounds of pure fatty alcohols selected from thegroup of pure cetyl alcohol, stearyl alcohol, and behenyl alcohol canalso be used. By “pure” herein, what is meant is that the compound has apurity of at least about 90%, and/or at least about 95%. These singlecompounds of high purity provide good rims ability from the hair whenthe consumer rinses off the composition.

The high melting point fatty compound can be included in the conditionercomposition at a level of from about 0.1% to about 20%, alternatively,from about 1% to about 15%, alternatively, from about 1.5% to about 8%by weight of the composition, in view of providing improved conditioningbenefits such as slippery feel during the application to wet hair,softness and moisturized feel on dry hair.

C. Aqueous Carrier

The conditioner gel matrix of the conditioner composition includes asecond aqueous carrier. Accordingly, the formulations of the conditionercomposition can be in the form of pourable liquids (under ambientconditions). Such compositions will therefore typically comprise asecond aqueous carrier, which is present at a level of from about 20 wt% to about 95 wt %, or from about 60 wt % to about 85 wt %. The secondaqueous carrier may comprise water, or a miscible mixture of water andorganic solvent, and in one aspect may comprise water with minimal or nosignificant concentrations of organic solvent, except as otherwiseincidentally incorporated into the composition as minor ingredients ofother components.

The second aqueous carriers useful in the conditioner compositioninclude water and water solutions of lower alkyl alcohols and polyhydricalcohols. The lower alkyl alcohols useful herein are monohydric alcoholshaving 1 to 6 carbons, in one aspect, ethanol and isopropanol. Thepolyhydric alcohols useful herein include propylene glycol, hexyleneglycol, glycerin, and propane diol.

Leave-on Treatment

The hair care composition of the present invention can be a leave-ontreatment. The leave-on treatment composition delivers consumer desiredhair conditioning or styling benefit in addition to scalp anti-dandruffefficacy benefit.

The leave-on treatment described herein comprises from about 0.1 wt % toabout 10.0 wt %, alternatively, from about 0.3 wt % to about 3.0 wt %,alternatively, from about 0.5% to about 2% of a 2-pyridinol-N-oxidematerial in an aqueous or a non-aqueous carrier. The leave-on treatmentcomposition also comprises from about 0.1 wt % to about 15.0 wt %,alternatively, from about 0.3 wt % to about 3.0 wt %, alternatively,from about 0.5% to about 2% of the chelator. The leave-on treatment mayalso comprise (1) one or more rheology modifiers.

The leave-on treatment may comprise an aqueous carrier. Accordingly, theformulations of the leave-on treatment can be in the form of pourableliquids (under ambient conditions). Such compositions will thereforetypically comprise an aqueous carrier, which is present at a level of atleast 20 wt %, from about 20 wt % to about 95 wt %, or from about 60 wt% to about 85 wt %. The aqueous carrier may comprise water, or amiscible mixture of water and organic solvent, and in one aspect maycomprise water with minimal or no significant concentrations of organicsolvent, except as otherwise incidentally incorporated into thecomposition as minor ingredients of other components. The aqueouscarriers useful in the leave-on treatment include water and watersolutions of lower alkyl alcohols and polyhydric alcohols. The loweralkyl alcohols useful herein are monohydric alcohols having 1 to 6carbons, in one aspect, ethanol and isopropanol. The polyhydric alcoholsuseful herein include propylene glycol, hexylene glycol, glycerin, andpropane diol.

Rheology Modifier/Thickener

The hair care compositions mentioned above may also contain one or morerheology modifier/thickener to adjust the rheological characteristics ofthe composition for better feel, in-use properties and the suspendingstability of the composition. For example, the rheological propertiesare adjusted so that the composition remains uniform during its storageand transportation and it does not drip undesirably onto other areas ofthe body, clothing or home furnishings during its use. Any suitablerheology modifier can be used. Alternatively, the leave-on treatment maycomprise from about 0.01% to about 3% of a rheology modifier,alternatively, from about 0.1% to about 1% of a rheology modifier.

The one or more rheology modifier may be selected from the groupconsisting of polyacrylamide thickeners, cationically modifiedpolysaccharides, associative thickeners, and mixtures thereof.Associative thickeners include a variety of material classes such as,for example: hydrophobically modified cellulose derivatives;hydrophobically modified alkoxylated urethane polymers, such asPEG-150/decyl alcohol/SMDI copolymer, PEG-150/stearyl alcohol/SMDIcopolymer, polyurethane-39; hydrophobically modified, alkali swellableemulsions, such as hydrophobically modified polypolyacrylates,hydrophobically modified polyacrylic acids, and hydrophobically modifiedpolyacrylamides; hydrophobically modified polyethers. These materialsmay have a hydrophobe that can be selected from cetyl, stearyl, oleayl,and combinations thereof, and a hydrophilic portion of repeatingethylene oxide groups with repeat units from 10-300, alternatively, from30-200, and alternatively, from 40-150. Examples of this class includePEG-120-methylglucose dioleate, PEG-(40 or 60) sorbitan tetraoleate,PEG-150 pentaerythrityl tetrastearate, PEG-55 propylene glycol oleate,PEG-150 distearate.

Non-limiting examples of additional rheology modifiers includeacrylamide/ammonium acrylate copolymer (and)polyisobutene (and)polysorbate 20; acrylamide/sodium acryloyldimethyl tauratecopolymer/isohexadecane/polysorbate 80; acrylates copolymer;acrylates/beheneth-25 methacrylate copolymer; acrylates/C10-C30 alkylacrylate crosspolymer; acrylates/steareth-20 itaconate copolymer;ammonium polyacrylate/Isohexadecane/PEG-40 castor oil; C12-16 alkylPEG-2 hydroxypropylhydroxyethyl ethylcellulose (HM-EHEC); carbomer;crosslinked polyvinylpyrrolidone (PVP); dibenzylidene sorbitol;hydroxyethyl ethylcellulose (EHEC); hydroxypropyl methylcellulose(HPMC); hydroxypropyl methylcellulose (HPMC); hydroxypropylcellulose(HPC); methylcellulose (MC); methylhydroxyethyl cellulose (MEHEC);PEG-150/decyl alcohol/SMDI copolymer; PEG-150/stearyl alcohol/SMDIcopolymer; polyacrylamide/C13-14 isoparaffin/laureth-7; polyacrylate13/polyisobutene/polysorbate 20; polyacrylate crosspolymer-6;polyamide-3; polyquaternium-37 (and) hydrogenated polydecene (and)trideceth-6; polyurethane-39; sodiumacrylate/acryloyldimethyltaurate/dimethylacrylamide; crosspolymer (and)isohexadecane (and) polysorbate 60; sodium polyacrylate. Exemplarycommercially-available rheology modifiers include ACULYN™ 28, Klucel MCS, Klucel H CS, Klucel G CS, SYLVACLEAR AF1900V, SYLVACLEAR PA1200V,Benecel E 10M, Benecel K35M, Optasense RMC70, ACULYN™33, ACULYN™46,ACULYN™22, ACULYN™44, Carbopol Ultrez 20, Carbopol Ultrez 21, CarbopolUltrez 10, Carbopol 1342, Sepigel™ 305, Simulgel™600, Sepimax Zen,and/or combinations thereof. A non exclusive list of suitable thickenersfor use herein include xanthan, guar, hydroxypropyl guar, scleroglucan,methyl cellulose, ethyl cellulose (commercially available as Aquacote(Registered trademark), hydroxyethyl cellulose (Natrosol (Registeredtrademark), carboxymethyl cellulose, hydroxypropylmethyl cellulose,microcrystalline cellulose, hydroxybutylmethyl cellulose, hydroxypropylcellulose (Klucel (Registered trademark), hydroxyethyl ethyl cellulose,cetyl hydroxyethyl cellulose (Natrosol (Registered trademark Plus 330),N-vinylpyrollidone (Povidone (Registered trademark), Acrylates/Ceteth-20Itaconate Copolymer (Structure (Registered trademark 3001),hydroxypropyl starch phosphate (Structure (Registered trademark ZEA),polyethoxylated urethanes or polycarbamyl polyglycol ester (e.g.PEG-150/Decyl/SMDI copolymer=Aculyn (Registered trademark 44,PEG-150/Stearyl/SMDI copolymer=Aculyn 46 (Registered trademark),trihydroxystearin (Thixcin (Registered trademark) acrylates copolymer(e.g. Aculyn (Registered trademark 33) or hydrophobically modifiedacrylate copolymers (e.g. Acrylates/Steareth-20 MethacrylateCopolymer=Aculyn (Registered trademark 22), and fatty alcohols, such ascetyl and stearyl alcohol, and combinations thereof.

pH

The hair care compositions mentioned above may also comprise one or morepH adjusting material. The compositions may have a pH in the range fromabout 2 to about 10, at 25° C. Alternatively, the shampoo composition,rinse-off conditioner composition, and/or leave-on treatment may have apH in the range of from about 2 to about alternatively, from about 3.5to about 5, alternatively, from about 5.25 to about 7.

The hair care compositions mentioned above may further comprise one ormore pH buffering agent. Suitable buffering agents are well known in theart and include for example ammonia/ammonium acetate mixture andmonoethanolamine (MEA). Alternatively, the shampoo composition and/orrinse-off conditioner composition may comprise citric acid, wherein thecitric acid acts as a buffer.

Additional Components

The shampoo composition, conditioner compositions, and/or leave-ontreatments described herein may optionally comprise one or moreadditional components known for use in hair care or personal careproducts, provided that the additional components are physically andchemically compatible with the essential components described herein, ordo not otherwise unduly impair product stability, aesthetics orperformance. Such additional components are most typically thosedescribed in reference books such as the CTFA Cosmetic IngredientHandbook, Second Edition, The Cosmetic, Toiletries, and FragranceAssociation, Inc. 1988, 1992. Individual concentrations of suchadditional components may range from about 0.001 wt % to about 10 wt %by weight of the hair care compositions.

Non-limiting examples of additional components for use in the hair carecompositions include conditioning agents, natural cationic depositionpolymers, synthetic cationic deposition polymers, other anti-dandruffagents, particles, suspending agents, paraffinic hydrocarbons,propellants, viscosity modifiers, dyes, non-volatile solvents ordiluents (water-soluble and water-insoluble), pearlescent aids, foamboosters, additional surfactants or nonionic cosurfactants,pediculocides, pH adjusting agents, perfumes, preservatives, proteins,skin active agents, sunscreens, UV absorbers, and vitamins.

1. Conditioning Agent

The hair care compositions may comprise one or more conditioning agents.Conditioning agents include materials that are used to give a particularconditioning benefit to hair. The conditioning agents useful in the haircare compositions of the present invention typically comprise awater-insoluble, water-dispersible, non-volatile, liquid that formsemulsified, liquid particles. Suitable conditioning agents for use inthe hair care composition are those conditioning agents characterizedgenerally as silicones, organic conditioning oils or combinationsthereof, or those conditioning agents which otherwise form liquid,dispersed particles in the aqueous surfactant matrix.

One or more conditioning agents are present from about 0.01 wt % toabout 10 wt %, from about 0.1 wt % to about 8 wt %, and from about 0.2wt % to about 4 wt %, by weight of the composition.

Silicone Conditioning Agent

The compositions of the present invention may contain one or moresilicone conditioning agents. Examples of the silicones includedimethicones, dimethiconols, cyclic silicones, methylphenylpolysiloxane, and modified silicones with various functional groups suchas amino groups, quaternary ammonium salt groups, aliphatic groups,alcohol groups, carboxylic acid groups, ether groups, epoxy groups,sugar or polysaccharide groups, fluorine-modified alkyl groups, alkoxygroups, or combinations of such groups. Such silicones may be soluble orinsoluble in the aqueous (or non-aqueous) product carrier. In the caseof insoluble liquid silicones, the polymer can be in an emulsified formwith droplet size of about 10 nm to about 30 micrometers

Organic Conditioning Materials

The conditioning agent of the compositions of the present invention mayalso comprise at least one organic conditioning material such as oil orwax, either alone or in combination with other conditioning agents, suchas the silicones described above. The organic material can benonpolymeric, oligomeric or polymeric. It may be in the form of oil orwax and may be added in the formulation neat or in a pre-emulsifiedform. Some non-limiting examples of organic conditioning materialsinclude, but are not limited to: i) hydrocarbon oils; ii) polyolefins,iii) fatty esters, iv) fluorinated conditioning compounds, v) fattyalcohols, vi) alkyl glucosides and alkyl glucoside derivatives; vii)quaternary ammonium compounds; viii) polyethylene glycols andpolypropylene glycols having a molecular weight of up to about 2,000,000including those with CTFA names PEG-20 200, PEG-400, PEG-600, PEG-1000,PEG-2M, PEG-7M, PEG-14M, PEG-45M and mixtures thereof.

Benefit Agents

The hair care composition may further comprise one or more additionalbenefit agents. The benefit agents comprise a material selected from thegroup consisting of anti-dandruff agents, anti-fungal agents, anti-itchagents, anti-bacterial agents, anti-microbial agents, moisturizationagents, anti-oxidants, vitamins, lipid soluble vitamins, perfumes,brighteners, enzymes, sensates, attractants, dyes, pigments, bleaches,and mixtures thereof.

The hair care composition may further comprise one or more additionalanti-dandruff active agents may be present in the hair care compositionand may include climbazole, ketoconazole, itraconazole, econazole,elubiol and combinations thereof.

The hair care compositions of the present invention may be presented intypical hair care formulations. They may be in the form of solutions,dispersion, emulsions, powders, talcs, encapsulated, spheres, spongers,solid dosage forms, foams, and other delivery mechanisms. Thecompositions of the present invention may be hair tonics, leave-on hairproducts such as treatment, and styling products, rinse-off hairproducts such as shampoos, and treatment products; and any other formthat may be applied to hair.

The hair care compositions may be provided in the form of a porous,dissolvable solid structure, such as those disclosed in U.S. PatentApplication Publication Nos. 2009/0232873; and 2010/0179083, which areincorporated herein by reference in their entirety. Accordingly, thehair care compositions comprise a chelator, a buffer system comprisingan organic acid, from about 23% to about 75% surfactant; from about 10%to about 50% water soluble polymer; and optionally, from about 1% toabout 15% plasticizer; such that the hair care composition is in theform of a flexible porous dissolvable solid structure, wherein saidstructure has a Percent open cell content of from about 80% to about100%.

The hair care compositions may be in the form of a porous dissolvablesolid structure comprising a chelator; a buffer system comprising anorganic acid from about 23% to about 75% surfactant; wherein saidsurfactant has an average ethoxylate/alkyl ratio of from about 0.001 toabout 0.45; from about 10% to about 50% water soluble polymer; and fromabout 1% to about 15% plasticizer; and wherein said article has adensity of from about 0.03 g/cm³ to about 0.20 g/cm³.

The hair care compositions may be in the form of a viscous liquidcomprising a chelator; a buffer system comprising an organic acid from5-20% surfactant and a polycarboxylate rheology modifier; wherein thepolycarboxylate is specifically chosen to be effective at the highelectrolyte levels resulting from the incorporation of the key buffersystem and chelator used for this invention. Non-limiting examplesinclude acrylates/C10-C30 alkyl acrylate crosspolymers such as CarbopolEDT2020, 1342, 1382, etc. from Lubrizol. Rheology benefits of theseactives in our embodiments include stability, ease of dispensing,smoothness of spreading, etc.

The hair care compositions are generally prepared by conventionalmethods such as are known in the art of making the compositions. Suchmethods typically involve mixing of the ingredients in one or more stepsto a relatively uniform state, with or without heating, cooling,application of vacuum, and the like. The compositions are prepared suchas to optimize stability (physical stability, chemical stability,photostability) and/or delivery of the active materials. The hair carecomposition may be in a single phase or a single product, or the haircare composition may be in a separate phases or separate products. Iftwo products are used, the products may be used together, at the sametime or sequentially. Sequential use may occur in a short period oftime, such as immediately after the use of one product, or it may occurover a period of hours or days.

EXAMPLES

The following examples illustrate embodiments of the invention describedherein. The exemplified oxidative dyeing, rinse-off conditioner, andshampoo compositions can be prepared by conventional formulation andmixing techniques. It will be appreciated that other modifications ofthe oxidative dyeing compositions, rinse-off conditioner compositions,and shampoo compositions within the skill of those in the formulationart can be undertaken without departing from the spirit and scope ofthis invention. All parts, percentages, and ratios herein are by weightunless otherwise specified. Some components may come from suppliers asdilute solutions. The amount stated reflects the weight percent of theactive material, unless otherwise specified.

Shampoo Composition Examples

Shampoo Shampoo Shampoo Example 1 Example 2 Example 3 Ingredients wt %wt % wt % Water Purified Q.S to 100 Q.S to 100 Q.S to 100 Sodium Laureth3 Sulfate 6.1 6.1 6.1 Sodium Lauryl Sulfate 10.0 10.0 10.0 Laureth-4 0.90.9 0.9 Dimethicone 330M cps 0.5 0.5 0.5 Glycol Distearate 1.5 1.5 1.5Polyquaternium-6 0.32 0.32 0.32 Sodium Benzoate 0.27 0.52 0.52 Citricacid 50% Solution 0.52 0.035 0.035 Methylchloroisothiazolinone/ 0.0351.66 1.66 methylisothiazolinone Sodium chloride 1.66 0.65 0.65 Fragrance0.65 0.05 0.05 DL-Panthenol 0.03 0.03 0.03 Panthenyl Ethyl ether 0.03 11 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2- 1 1 1 pyridonemonoethanolamine salt¹ Diethylenetriaminepentakis(methylenephosphonic 1acid) (DTPMP) Diethylenetriaminepentaacetic acid (DTPA) 1Desferrioxamine 1 Shampoo Shampoo Shampoo Shampoo Example 4 Example 5Example 6 Example 7 Ingredients wt % wt % wt % wt % Water Purified Q.Sto 100 Q.S to 100 Q.S to 100 Q.S to 100 Sodium Laureth 3 Sulfate 6.1 6.16.1 6.1 Sodium Lauryl Sulfate 10.0 10.0 10.0 10.0 Laureth-4 0.9 0.9 0.90.9 Dimethicone 330M cps 0.5 0.5 0.5 0.5 Glycol Distearate 1.5 1.5 1.51.5 Polyquaternium-6 0.32 0.32 0.32 0.32 Sodium Benzoate 0.27 0.27 0.270.27 Citric acid 50% Solution 0.52 0.52 0.52 0.52Methylchloroisothiazolinone/ 0.035 0.035 0.035 0.035methylisothiazolinone Sodium chloride 1.66 1.66 1.66 1.66 Fragrance 0.650.65 0.65 0.65 DL-Panthenol 0.03 0.03 0.03 0.03 Panthenyl Ethyl ether0.03 0.03 0.03 0.03 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)- 0.50.75 0.1 10 2-pyridone monoethanolamine salt¹Diethylenetriaminepentakis(methylenephosphonic 5 5 15 0.1 acid) (DTPMP)¹Synonym of the material is piroctone olamine, available fromCombi-Blocks, Inc. Additional Shampoo Examples Shampoo Shampoo ShampooIngredient Example 8 Example 9 Example 10 Sodium lauryl ether sulfate(SLE3S) 6 6 Sodium cocoyl isethionate Sodium lauryl sulfate (SLS) 1.5 77 Sodium lauryl ether sulfate (SLE1S) 10.5 Disodium laurethsulfosuccinate Sodium lauryl sulfoacetate Sodium Lauroyl SarcosinateCocoamidopropyl Hydroxysultaine Cocoamidopropyl Betaine 1 2 2 Coconutmonoethanol amide (CMEA) 0.85 0.85 Dimethicone 1 1 1 Ethylene glycoldistearate (EGDS) 1.5 1.5 1.5 Jaguar ® C500¹ 0.25 0.25 SyntheticCationic Polymer AMT² 0.1 Polydiallyldimethylammonium chloride (DADMAC)Excel Guar³ 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2- 1 1 1pyridone monoethanolamine salt¹Diethylenetriaminepentakis(methylenephosphonic 1 1 1 acid) (DTPMP) pH 66 6 Water-USP Purified & Minors Q.S. to 100 Q.S. to 100 Q.S. to 100Shampoo Shampoo Shampoo Example Example Example Ingredient 11 12 13Sodium lauryl ether sulfate (SLE3S) 6 9 Sodium cocoyl isethionate 8.5Sodium lauryl sulfate (SLS) 7 6 Sodium lauryl ether sulfate (SLE1S)Disodium laureth sulfosuccinate 8.5 Sodium lauryl sulfoacetate 2.5Sodium Lauroyl Sarcosinate 0.75 Cocoamidopropyl Hydroxysultaine 1.5Cocoamidopropyl Betaine 2 2 2 Coconut monoethanol amide (CMEA)Dimethicone 1 Ethylene glycol distearate (EGDS) 1.5 Jaguar ® C500²Synthetic Cationic Polymer AMT³ 0.15 Polydiallyldimethylammoniumchloride 0.1 1 (DADMAC) Excel Guar⁴ 0.1 11-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2- 1 1 1 pyridonemonoethanolamine salt¹ Diethylenetriaminepentakis(methylenephosphonic 11 1 acid) (DTPMP) pH 6 6 6 Water-USP Purified & Minors Q.S. to 100 Q.S.to 100 Q.S. to 100 ¹Synonym of the material is piroctone olamine,available from Combi-Blocks, Inc. ²Cationic polymer derived from anatural gum with low aqueous viscosity ³Cationic synthetic copolymer⁴Cationic plant derived polymer

Examples of Shampoo Compositions Containing Gel Network Shampoo GelNetwork Method of Preparation

The shampoo gel network may be formed by combining fatty alcohols andsurfactants in the ratio of 1:1 to 40:1, alternatively, from 2:1 to20:1, alternatively, from 3:1 to 10:1. The formation of a shampoo gelnetwork involves heating a dispersion of the fatty alcohol in water withthe surfactant to a temperature above the melting point of the fattyalcohol. During the mixing process, the fatty alcohol melts, allowingthe surfactant to partition into the fatty alcohol droplets. Thesurfactant brings water along with it into the fatty alcohol. Thischanges the isotropic fatty alcohol drops into liquid crystalline phasedrops. When the mixture is cooled below the chain melt temperature, theliquid crystal phase is converted into a solid crystalline gel network.

Shampoo Shampoo Shampoo Ingredient Ex. 14 Ex. 15 Ex. 16 Water-USPPurified & Minors Q.S. Q.S. Q.S. to 100 to 100 to 100 Sodium LaurethSulfate (SLE1S) 12 12 14 Sodium Lauryl Sulfate (SLS) 1.5 1.5Cocoamidoproply Betaine (CapB) 1.7 1.7 1.7 Gel Network 1 2 2 GuarHydroxypropyltrimonium 0.3 0.3 0.3 Chloride Polyquaternium 6 (DADMAC)0.1 0.1 0.1 Ethylene Glycol Distearate 1.5 1.5 Trihydroxy Stearin(Thixcin) 0.1 Dimethicone/Dimethiconol 1 0.5 0.5 Citric Acid 1 1 1Sodium Citrate Dihydrate 1 1 1 Acrylates/C10-C30 alkyl acrylatecrosspolymers Kathon 0.0005 0.0005 0.0005 Sodium Benzoate 0.25 0.25 0.251-Hydroxy-4-methyl-6-(2,4,4- 1 1 1 trimethylpentyl)-2-pyridonemonoethanolamine salt¹ Diethylenetriaminepentaacetic 1 1 1 acid (DTPA)Perfume 0.8 0.8 0.8 Sodium Chloride² 0-3 0-3 0-3 Sodium XyleneSulfonate² 0-3 0-3 0-3 ¹Synonym of the material is piroctone olamine,available from Combi-Blocks, Inc. ²Level adjusted to reach desiredviscosity

Examples of Rinse-Off Conditioner Compositions

Rinse-off Rinse-off Conditioner Ex 1 Conditioner Ex 2 Ingredients Wt %Wt % Amodimethicone 10000 cps 0.5 0.5 Citric acid anhydrous 0.13 0.13DL-Panthenol 56% solution 0.054 0.054 Panthenyl Ethyl ether 0.03 0.03Perfume 0.5 0.5 Hydroxypropyl guar (Jaguar HP- 0.35 0.35 105)Quaternium-18 0.75 0.75 Steramidopropyldimethylamine 1 1 Grycerylstearate 0.25 0.25 Cetearyl alcohol and Polysorbate 0.5 0.5 60 Emulsion¹Cetyl alcohol 1.2 1.2 Stearyl alcohol 0.8 0.8 Benzyl alcohol 0.4 0.4Methylchloroisothiazolinone/ 0.033 0.033 methylisothiazolinone1-Hydroxy-4-methyl-6-(2,4,4- 1 1 trimethylpentyl)-2-pyridonemonoethanolamine salt¹ Diethylenetriaminepentaacetic acid 1 (DTPA)Desferrioxamine 1 Water Purified QS to 100 QS to 100 Rinse-off Rinse-offIngredients Conditioner Ex. 3 Conditioner Ex. 4 Water-USP Purified &Minors QS to 100% QS to 100% BTMS² 3.76 3.76 Cetyl alcohol 1.3 1.3Stearyl alcohol 3.2 3.2 Soy Oligomer³ 1.0 — Aminosilicone⁴ — 1.01-Hydroxy-4-methyl-6-(2,4,4- 1 1 trimethylpentyl)-2-pyridonemonoethanolamine salt¹ Diethylenetriaminepentakis 1 1(methylenephosphonic acid) (DTPMP) Perfume 0.5 0.5 Benzyl Alcohol 0.40.4 Preservatives 0.03 0.03 Rinse-off Rinse-off Ingredients ConditionerEx. 5 Conditioner Ex. 6 Water-USP Purified & Minors QS to 100% QS to100% BTMS² 3.76 3.76 Cetyl alcohol 1.3 1.3 Stearyl alcohol 3.2 3.2 SoyOligomer³ — — Aminosilicone⁴ 1 1 1-Hydroxy-4-methyl-6-(2,4,4- 1 1trimethylpentyl)-2-pyridone monoethanolamine salt¹Diethylenetriaminepentaacetic 1 acid (DTPA) Desferrioxamine 1 Perfume0.5 0.5 Benzyl Alcohol 0.4 0.4 Preservatives 0.03 0.03 ¹Synonym of thematerial is piroctone olamine, available from Combi-Blocks, Inc.²Behenyltrimethylammonium methylsulfate from Feixiang. ³HY-3050 from DowCorning. ⁴Y-14945; 10,000 cP aminodimethicone from Momentive

Examples of Leave-on Treatment Compositions

Ingredients LOT Ex. 1 LOT Ex. 2 Dipropyleneglycol Monomethylether 0.50.5 Disodium Ethylene diamine diacetic acid 0.141 0.141 PEG-40Hydrogenated Castor Oil 0.5 0.5 Polysorbate 80² 0.12 0.12 Amodimethiconeand Cetrimonium 1.81 1.81 Chloride Polyquaternium 11³ 1.335 1.335 CitricAcid Anhydrous 0.08 0.08 2-Amino-2-methyl-1-propanol 0.1 0.1 DMDMHydantoin (55%)⁴ 0.37 — Benzyl Alcohol — 0.4 Neolone 950 Preservative⁵ —0.053 Perfume 0.2 0.2 1-Hydroxy-4-methyl-6-(2,4,4- 1 1trimethylpentyl)-2-pyridone monoethanolamine salt¹Diethylenetriaminepentaacetic acid (DTPA) 1 Desferrioxamine 1 Water-USPPurified & Minors QS to 100% QS to 100% ¹Synonym of the material ispiroctone olamine, available from Combi-Blocks, Inc. ²Nonionicsurfactant and emulsifier derived frompolyethoxylated sorbitan and oleicacid ³Copolymer of vinylpyrrolidone and quaternized dimethylaminoethylmethacrylate ⁴1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione⁵Preservative containing Methylisothiazolinone

Additional Examples/Combinations

-   -   A. A hair care composition comprising:        -   a) from about 0.1% to about 10% of a substituted or            unsubstituted 2-pyridinol-N-oxide material;        -   b) from about 0.01% to about 15% of an iron chelator wherein            the combination of the iron chelator and the substituted or            unsubstituted 2-pyridinol-N-oxide material has a modified            fractional inhibitor concentration of less than or equal to            about 100 ppm and is selected from the group consisting of:            -   i. Iron chelators represented by the following                structure:

-   -   -   -   where R¹⁰, R¹¹, R¹², R¹³, R¹⁴ are selected from the                group consisting of            -   M¹M²PO₃, CO₂M¹, and mixtures thereof

        -   where M¹ and M² are independently selected from the group            consisting of H, ammonium, and a metal salt, wherein the            metal salt is selected from the group consisting of sodium,            potassium, calcium, magnesium, and aluminum;            -   ii. Iron chelators represented by the following                structure:

-   -   -   -   where a is an integer from 2 to 7 wherein any of the CH₂                groups in this unit may be substituted with alkyl or                aryl units that may contain heteroatoms (S, N, O, Cl, F,                Br or I)            -   where b is an integer from 1 to 7 wherein any of the CH₂                groups in this unit may be substituted with alkyl or                aryl units that may contain heteroatoms (S, N, O, Cl, F,                Br or I)            -   where R¹⁶ is H or (CH₂)_(n), where n in an integer from                1 to 6 or is a CH₂ linker unit that may be further                substituted at any CH₂ group in the chain with alkyl or                aryl units that may contain heteroatoms (S, N, O, Cl, F,                Br, or I);            -   and mixtures of i and ii thereof;

        -   c) from about 40% to about 95% aqueous carrier.

    -   B, The hair care composition according to Paragraph A, wherein        the iron chelator has a log K₁ greater than about 16.

    -   C. The hair care composition according to Paragraph A-B, wherein        the iron chelator has a log K₁ greater than about 20.

    -   D. The hair care composition according to Paragraph A-C, where        the substituted or unsubstituted 2-pyridinol-N-oxide material        comprises the molecular structure:

-   -   -   wherein R¹, R², R³, R⁴ are independently selected from the            group consisting of H, Cl, Br, I, F, NO, NO₂, (CH₂)_(n)G,            and mixtures thereof, wherein each G is independently            selected from the group consisting of (O)_(m)SO₃M³,            (O)_(m)CO₂M³, (O)_(m)C(O)(R⁵), (O)_(m)C(O)N(R⁵R⁶),            (O)_(m)CN, (O)_(m)(R⁵), N(R⁵R⁶), and mixtures thereof,            -   wherein m is 0 or 1,            -   and wherein n is an integer from 0 to 4,            -   and wherein R⁵ and R⁶ are independently selected from                the group consisting of H and a substituted or                unsubstituted C1-C12 organic group, and            -   wherein M³ is selected from the group consisting of H, a                substituted or unsubstituted C₁-C₁₂ organic group,                +N(R⁷R⁸R⁹R¹⁰), and 1/q M′q+ wherein M′ is selected from                the group consisting of an alkali metal of charge q and                an alkaline earth metal of charge q, where R7, R8, R9,                and R10 are independently selected from the group                consisting of H and a substituted or unsubstituted                C1-C12 organic group, and wherein any pair of vicinal                groups, R¹ and R², R² and R³, R³ and R⁴, may be taken                together to form another five- or six-membered aromatic                or aliphatic ring optionally substituted with one or                more groups selected from the group consisting of Cl,                Br, I, F, NO, NO₂, CN, (CH₂)_(n)G, and mixtures thereof.

    -   E. The hair care composition according to Paragraph A-D, wherein        R¹, R², R³, R⁴ are selected from the group consisting of H, Cl,        and (CH₂)_(n)G, wherein G is selected from the group consisting        of (O)_(m)SO₃M³, (O)_(m)CO₂M³, (O)_(m)C(O)(R⁵), (O)_(m)CN, and        (O)_(m)(R⁵), wherein m is 0 or 1.

    -   F. The hair care composition according to Paragraph A-E, wherein        said substituted or unsubstituted 2-pyridinol-N-oxide material        is 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone        monoethanolamine salt.

    -   G. The hair care composition according to Paragraph A-F, wherein        wherein the iron chelator is selected from the group consisting        of diethylenetriaminepentaacetic acid (DTPA),        Diethylenetriaminepentakis (methylenephosphonic acid) (DTPMP),        Desferrioxamine and mixtures thereof.

    -   H. The hair care composition according to Paragraph A-G, wherein        the iron chelator is diethylenetriaminepentaacetic acid (DTPA).

    -   I. The hair care composition according to Paragraph A-H, wherein        the iron chelator is Diethylenetriaminepentakis        (methylenephosphonic acid) (DTPMP).

    -   J. The hair care composition according to Paragraph A-I, wherein        the iron chelator is Desferrioxamine

    -   K. The hair care composition according to Paragraph A-J, wherein        the substituted or unsubstituted 2-pyridinol N-oxide material is        from about 0.3% to about 3%.

    -   L. The hair care composition according to Paragraph A-K, the        substituted or unsubstituted 2-pyridinol N-oxide material is        from about 0.5% to about 2%.

    -   M. The hair care composition according to Paragraph A-L, wherein        the iron chelator is from about 0.3% to about 6%.

    -   N. The hair care composition according to Paragraph A-M, wherein        the iron chelator is from about 0.5% to about 4%.

    -   O. The hair care composition according to Paragraph A-N, wherein        the modified fractional inhibitor concentration of less than or        equal to about 70 ppm.

    -   P. The hair care composition according to Paragraph A-O, wherein        the modified fractional inhibitor concentration of less than or        equal to about 60 ppm.

    -   Q. The hair care composition according to Paragraph A-P, wherein        the modified fractional inhibitor concentration of less than or        equal to about 50 ppm.

    -   R. The hair care composition according to Paragraph A-Q, wherein        the hair composition is a shampoo composition further        comprising:        -   a. from about 5% to about 45% of one or more detersive            surfactants, by weight of the shampoo composition; and        -   b. from about 75% to about 95% of an aqueous carrier, by            weight of the shampoo composition.

    -   S. The hair care composition according to Paragraph A-R, wherein        the hair composition is a rinse-off hair conditioner composition        further comprising a) from about 50% to about 80% of an aqueous        carrier, by weight of the conditioner composition and b) a        conditioner gel matrix comprising: (i) from 0.1% to about 20% of        one or more high melting point fatty compound, by weight of the        conditioner gel matrix; (ii) from about 0.1% to about 10% of a        cationic surfactant system, by weight of the conditioner gel        matrix; and (iii) at least 20% of a second aqueous carrier, by        weight of the conditioner gel matrix.

    -   T. The hair care composition according to Paragraph A-S, wherein        the hair composition is a leave-on treatment composition further        comprising: (i) from 0.1% to about 20% of one or more high        melting point fatty compound, by weight of the conditioner gel        matrix; (ii) from about 0.1% to about 10% of a cationic        surfactant system, by weight of the conditioner gel matrix;        and (iii) at least 20% of a second aqueous carrier, by weight of        the conditioner gel matrix.

    -   U. The hair care composition according to Paragraph A-T, wherein        the hair composition is a leave-on treatment composition further        comprising 0.01-4% of a rheology modifier.

    -   V. The hair care composition according to Paragraph A-U, wherein        the rheology modifier is a polymeric rheology modifier (or        Polyacrylamide & C13-14 Isoparaflin & Laureth-7.

    -   W. The hair care composition according to Paragraph A-V, wherein        the hair composition further comprises one or more additional        anti-dandruff active agents selected from the group consisting        of climbazole, ketoconazole, itraconazole, econazole, elubiol        and combinations thereof.

    -   X. Use of the hair care composition according to Paragraph A-X,        for treating hair.

    -   Y. Use according to Paragraph X, for treating cosmetically hair        against dandruff (without cosmetic, I am afraid that we fall        into a medical use).

    -   Y1. Use according to Paragraph X, for improving the cosmetic        aspect of hair and the scalp against dandruff (without cosmetic,        I am afraid that we fall into a medical use).

    -   Z. Use according to Paragraph X, for inhibiting the growth of        Malassezia.

    -   Z1. Use according to Paragraph X for providing an anti-fungal        activity onto hair.

    -   A1. Use according to Paragraph X for mitigating anti-dandruff        onto hair.

    -   A2. Use according to Paragraph X, wherein the hair composition        comprises from 0.1% to 10% of        11-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone        monoethanolamine salt and from 0.01% to a 15% of an iron        chelator which is selected from the group consisting of        diethylenetriaminepentaacetic acid (DTPA),        Diethylenetriaminepentakis (methylenephosphonic acid) (DTPMP),        Desferrioxamine, and mixtures thereof.

    -   A3. The hair care composition according to Paragraph A-W for use        as an antifungal agent.

    -   A4. The hair care composition according to Paragraph A3, for use        as an antifungal agent against Malassezia.

The dimensions and values disclosed herein are not to be understood asbeing strictly limited to the exact numerical values recited. Instead,unless otherwise specified, each such dimension is intended to mean boththe recited value and a functionally equivalent range surrounding thatvalue. For example, a dimension disclosed as “40 mm” is intended to mean“about 40 mm.”

All documents cited in the Detailed Description of the Invention are, inrelevant part, incorporated herein by reference; the citation of anydocument is not to be construed as an admission that it is prior artwith respect to the present invention. To the extent that any meaning ordefinition of a term in this document conflicts with any meaning ordefinition of the same term in a document incorporated by reference, themeaning or definition assigned to that term in this document shallgovern.

While particular embodiments of the present invention have beenillustrated and described, it would be obvious to those skilled in theart that various other changes and modifications can be made withoutdeparting from the spirit and scope of the invention. It is thereforeintended to cover in the appended claims all such changes andmodifications that are within the scope of this invention.

What is claimed is:
 1. A hair care composition comprising: a) from about0.1% to about 10% of a substituted or unsubstituted 2-pyridinol-N-oxidematerial; b) from about 0.01% to about 15% of an iron chelator whereinthe combination of the iron chelator and the substituted orunsubstituted 2-pyridinol-N-oxide material has a modified fractionalinhibitor concentration of less than or equal to about 100 ppm and isselected from the group consisting of: i. Iron chelators represented bythe following structure:

where R¹⁰, R¹¹, R¹², R¹³, R¹⁴ are selected from the group consisting ofM¹M²PO₃, CO₂M¹, and mixtures thereof where M¹ and M² are independentlyselected from the group consisting of H, ammonium, and a metal salt,wherein the metal salt is selected from the group consisting of sodium,potassium, calcium, magnesium, and aluminum; ii. Iron chelatorsrepresented by the following structure:

where a is an integer from 2 to 7 wherein any of the CH₂ groups in thisunit may be substituted with alkyl or aryl units that may containheteroatoms (S, N, O, Cl, F, Br or I) where b is an integer from 1 to 7wherein any of the CH₂ groups in this unit may be substituted with alkylor aryl units that may contain heteroatoms (S, N, O, Cl, F, Br or I)where R¹⁶ is H or (CH₂)_(n), where n in an integer from 1 to 6 or is aCH₂ linker unit that may be further substituted at any CH₂ group in thechain with alkyl or aryl units that may contain heteroatoms (S, N, O,Cl, F, Br, or I) and mixtures thereof; and mixtures of i and ii thereof;b. from about 40% to about 95% aqueous carrier.
 2. The hair carecomposition of claim 1 wherein the iron chelator has a log K₁ greaterthan about
 16. 3. The hair care composition of claim 1 wherein the ironchelator has a log K₁ greater than about
 20. 4. The hair carecomposition of claim 1 where the substituted or unsubstituted2-pyridinol-N-oxide material comprises the molecular structure:

wherein R¹, R², R³, R⁴ are independently selected from the groupconsisting of H, Cl, Br, I, F, NO, NO₂, (CH₂)_(n)G, and mixturesthereof, wherein each G is independently selected from the groupconsisting of (O)_(m)SO₃M³, (O)_(m)CO₂M³, (O)_(m)C(O)(R⁵),(O)_(m)C(O)N(R⁵R⁶), (O)_(m)CN, (O)_(m)(R⁵), N(R⁵R⁶), and mixturesthereof, wherein m is 0 or 1, and wherein n is an integer from 0 to 4,and wherein R⁵ and Ware independently selected from the group consistingof H and a substituted or unsubstituted C1-C12 organic group, andwherein M³ is selected from the group consisting of H, a substituted orunsubstituted C₁-C₁₂ organic group, ⁺N(R⁷R⁸R⁹R¹⁰), and 1/q M′q+ whereinM′ is selected from the group consisting of an alkali metal of charge qand an alkaline earth metal of charge q, where R7, R8, R9, and R10 areindependently selected from the group consisting of H and a substitutedor unsubstituted C₁-C₁₂ organic group, and wherein any pair of vicinalgroups, R¹ and R², R² and R³, R³ and R⁴, may be taken together to formanother five- or six-membered aromatic or aliphatic ring optionallysubstituted with one or more groups selected from the group consistingof Cl, Br, I, F, NO, NO₂, CN, (CH₂)_(n)G, and mixtures thereof.
 5. Thehair care composition of claim 4, wherein R¹, R², R³, R⁴ are selectedfrom the group consisting of H, Cl, and (CH₂)_(n)G, wherein G isselected from the group consisting of (O)_(m)SO₃M³, (O)_(m)CO₂M³,(O)_(m)C(O)(R⁵), (O)_(m)CN, and (O)_(m)(R⁵), wherein m is 0 or
 1. 6. Thehair care composition of claim 1, wherein said substituted orunsubstituted 2-pyridinol-N-oxide material is1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolaminesalt.
 7. The hair care composition of claim 1 wherein the iron chelatoris selected from the group consisting of diethylenetriaminepentaaceticacid (DTPA), Diethylenetriaminepentakis (methylenephosphonic acid)(DTPMP), Desferrioxamine and mixtures thereof.
 8. The hair carecomposition of claim 1 wherein the iron chelator isdiethylenetriaminepentaacetic acid (DTPA).
 9. The hair care compositionof claim 1 wherein the iron chelator is Diethylenetriaminepentakis(methylenephosphonic acid) (DTPMP).
 10. The hair care composition ofclaim 1 wherein the iron chelator is Desferrioxamine.
 11. The hair carecomposition of claim 1 wherein the substituted or unsubstituted2-pyridinol N-oxide material is from about 0.3% to about 3%.
 12. Thehair care composition of claim 1 wherein the substituted orunsubstituted 2-pyridinol N-oxide material is from about 0.5% to about2%.
 13. The hair care composition of claim 1 wherein the iron chelatoris from about 0.3% to about 6%.
 14. The hair care composition of claim 1wherein the iron chelator is from about 0.5% to about 4%.
 15. The haircare composition of claim 1 wherein the modified fractional inhibitorconcentration of less than or equal to about 70 ppm.
 16. The hair carecomposition of claim 1 wherein the modified fractional inhibitorconcentration of less than or equal to about 60 ppm.
 17. The hair carecomposition of claim 1 wherein the modified fractional inhibitorconcentration of less than or equal to about 50 ppm.
 18. The hair carecomposition of claim 1 wherein the hair composition is a shampoocomposition further comprising: a. from about 5% to about 45% of one ormore detersive surfactants, by weight of the shampoo composition; and b.from about 75% to about 95% of an aqueous carrier, by weight of theshampoo composition.
 19. The hair care composition of claim 1 whereinthe hair composition is a rinse-off hair conditioner composition furthercomprising a) from about 50% to about 80% of an aqueous carrier, byweight of the conditioner composition and b) a conditioner gel matrixcomprising: (i) from 0.1% to about 20% of one or more high melting pointfatty compound, by weight of the conditioner gel matrix; (ii) from about0.1% to about 10% of a cationic surfactant system, by weight of theconditioner gel matrix; and (iii) at least 20% of a second aqueouscarrier, by weight of the conditioner gel matrix.
 20. The hair carecomposition of claim 1 wherein the hair composition is a leave-ontreatment composition further comprising: (i) from 0.1% to about 20% ofone or more high melting point fatty compound, by weight of theconditioner gel matrix; (ii) from about 0.1% to about 10% of a cationicsurfactant system, by weight of the conditioner gel matrix; and (iii) atleast 20% of a second aqueous carrier, by weight of the conditioner gelmatrix.
 21. The hair care composition of claim 1 wherein the haircomposition is a leave-on treatment composition further comprising0.01-4% of a rheology modifier.
 22. The hair care composition of claim21 wherein the rheology modifier is a polymeric rheology modifier (orPolyacrylamide & C13-14 Isoparaflin & Laureth-7.
 23. The hair carecomposition of claim 1 wherein the hair composition further comprisesone or more additional anti-dandruff active agents selected from thegroup consisting of climbazole, ketoconazole, itraconazole, econazole,elubiol and combinations thereof.